Vanguard DAPP+L4 contains attenuated strains of CDV, CAV2, CPiV, CPV, and inactivated whole cultures of the four Leptospira serovars mentioned above.
The high-titer, low-passage CPV virus in Vanguard DAPP+L4 is highly immunogenic and capable of stimulating active immunity in the presence of maternal antibodies. This product does not contain CPV type 2c. Cross protection against CPV type 2c was demonstrated in vaccinated puppies challenged 5 weeks following second vaccination.